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The discovery equips dog breeders with the tools to eliminate that trait from the Dalmatian breed and yields clues to the cause of similar problems in humans. The findings will be published Nov. 7 in the scientific journal Public Library of Science.

“This defect, which in dogs is peculiar to the entire Dalmatian breed, has been reported for nearly a century and was probably unintentionally introduced as breeders worked to select more distinctive spotting patterns,” said veterinary geneticist Danika Bannasch, lead author on the study.

“It is now possible that this trait can be removed from the breed by crossing Dalmatians with the normal offspring of the original Dalmatian-pointer breeding that occurred in the early 1970s,” she said.

By Dec. 1, the Veterinary Genetics Laboratory in UC Davis’ School of Veterinary Medicine will begin offering DNA testing for the mutation in dogs to allow breeders to eliminate the trait. Information on the testing program will be available online at UC Davis Veterinary Genetics Laboratory

The researchers collected DNA samples as well as urine samples from hundreds of dogs to identify the gene responsible for high levels of uric acid. Genetic analysis of dogs that are a cross between pointers and Dalmatians revealed that gene to be SLC2A9, a gene that recently has been reported to be important in regulating uric acid levels in humans. DNA analysis showed that mutations in the SLC2A9 gene were responsible for the elevated uric acid in the Dalmatians.

The same mutations also were present in some bulldogs and black Russian terriers, breeds that are not known to be closely related to Dalmatians. This suggests that the gene mutation must be quite old, even predating formation of the Dalmatian breed. Alternatively, the mutation could have been introduced to those breeds by crosses between breeds, the researchers noted.

Because the gene mutation does not always occur in bulldogs and black Russian terriers, breeders can simply use genetic selection to eliminate the unhealthy trait from those breeds. In Dalmatians, however, the mutation occurs in all dogs, forcing breeders to look outside of the breed to correct the problem. Download the journal in PDF format

source:www.physorg.com

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Book Description
This updated edition offers some significant revisions designed to increase its usefulness for veterinary and veterinary technician students. These include: expanded introductory text for each chapter; expanded legends on a selective basis throughout the book; standardized terms to conform with the Nomina Anatomica Veterinaria, 1996 Edition; views at higher magnification; twenty new color figures; detailed Glossary of Terms.

Book Info
Rutgers Univ., Camden, NJ. Practical atlas provides students with a foundation in the understanding and interpreting histologic and cytologic preparations. Includes more than 100 enlargements of selected color figures. All of the original Kodachrome slides have been rephotographed and re-labeled. Previous edition: c1990.
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The first and most important tool is a working knowledge of your horse’s feet and his shoeing needs. You should be able to tell when a shoe is loose, sprung or shifted and know what has to be done about it while waiting for the farrier. You should also know what a well trimmed hoof looks like so that if there are sharp edges, splits, chips or broken hoof wall you can correctly dress them. There will be times when a nail or a shoe will have to be removed from the horse’s foot. View Product Details

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