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Dalmatian bladder stones caused by gene that regulates uric acid in humans

The discovery equips dog breeders with the tools to eliminate that trait from the Dalmatian breed and yields clues to the cause of similar problems in humans. The findings will be published Nov. 7 in the scientific journal Public Library of Science.

“This defect, which in dogs is peculiar to the entire Dalmatian breed, has been reported for nearly a century and was probably unintentionally introduced as breeders worked to select more distinctive spotting patterns,” said veterinary geneticist Danika Bannasch, lead author on the study.

“It is now possible that this trait can be removed from the breed by crossing Dalmatians with the normal offspring of the original Dalmatian-pointer breeding that occurred in the early 1970s,” she said.

By Dec. 1, the Veterinary Genetics Laboratory in UC Davis’ School of Veterinary Medicine will begin offering DNA testing for the mutation in dogs to allow breeders to eliminate the trait. Information on the testing program will be available online at UC Davis Veterinary Genetics Laboratory

The researchers collected DNA samples as well as urine samples from hundreds of dogs to identify the gene responsible for high levels of uric acid. Genetic analysis of dogs that are a cross between pointers and Dalmatians revealed that gene to be SLC2A9, a gene that recently has been reported to be important in regulating uric acid levels in humans. DNA analysis showed that mutations in the SLC2A9 gene were responsible for the elevated uric acid in the Dalmatians.

The same mutations also were present in some bulldogs and black Russian terriers, breeds that are not known to be closely related to Dalmatians. This suggests that the gene mutation must be quite old, even predating formation of the Dalmatian breed. Alternatively, the mutation could have been introduced to those breeds by crosses between breeds, the researchers noted.

Because the gene mutation does not always occur in bulldogs and black Russian terriers, breeders can simply use genetic selection to eliminate the unhealthy trait from those breeds. In Dalmatians, however, the mutation occurs in all dogs, forcing breeders to look outside of the breed to correct the problem. Download the journal in PDF format

source:www.physorg.com

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  • Oh Behave!: Dogs from Pavlov to Premack to Pinker (Paperback)
     Oh Behave!: Dogs from Pavlov to Premack to Pinker $13.57 & eligible for FREE Super Saver Shipping on orders over $25. Buy Now Section 1: Behavior Chemistry and Constraints: How We Choose Our Dogs Test Your Dog’s IQ Observation vs Interpretation Wolf Behavior Patterns Social Organization Models; A Mind Virus Neonate Puppies The Owner Signature: How We Build Our Dogs What Is Play? Dog Cognition Research Ambivalence and Conflicting Motivation Nutrition and Behavior Malingering: Do Dogs Ever Fake It? Section 2: Training Dog Training Philosophies Puritanism and Reward Training Pavlov in Everyday Life Prompting and Fading Shaping Exploiting Premack’s Principle Ringwise Dogs Training Deaf Dogs Managing Barrier Frustration Home Alone Training Scratching the Rescue Itch Section 3: Behavior problems A Problem According to Whom? Marking Barking Oh Behave! Love and Mounting Car Whining Behavior Problems in Geriatric Dogs Understanding and Executing Time Outs for Dogs High Performance Dogs Dogs and Cats Small Dog Syndrome Tales From The Potty Training Trenches Section 4: Fear & Anxiety Better Safe Than Sorry: Fear Compulsive Disorders in Dogs Understanding Psychotropic Medications for Dogs Desensitization to Veterinarian Visits Separation Anxiety Do Dogs Pick Up Their Owners’ Prejudices? Section 5: Aggression The Dog Bite Epidemic Aggression Prognosis Estimates Resource Guarding in Puppies Resource Guarding Prevention Fighting Dog Rehabilitation Predatory Drift Breed Specific Legislation and Behavior Section 6: Genetics & Evolution My Genes Made Me Do It Genes and Behavior Adaptive Significance of Various Dog Behaviors Chows vs Border Collies Theories of Domestication Breeder Power Dog Moms and Other Evolutionary Misfires Last night, I read through the chapters in section 1. I have to say that I think that each chapter is going to be hit or miss with me. For example, the chapter called “Chemistry and Constraints: How We Choose Our Dogs” wasn’t that enlightening. Jean even admits that there isn’t a lot of research about how we choose our dogs, and she confesses, “So, using a wholly rigorous approach — mulling it over in the shower and chatting with some dog friends — I have generated the following list of dog choice factors.” At least she’s honest, but in a book that throws Pavlov, Premack, and Pinker in the title, I figured the conclusions would be based more in research than mulling it over. On the other hand, I really enjoyed the chapter called “Observation vs Interpretation.” She contrasts the behaviorism school of thought versus other interpreters, and I’m pretty sure she’s implying folks like Caesar Millan in the later case. It’s pretty clear from the subtext that she doesn’t like the whole “the dog is displaying his dominance” school of thought. In the end, I think I’ll end up marking the chapters that are worth reading, and then taking the bibliography in the back and doing some further reading. This book is almost like a series of blog posts strung together, and although that’s not really what I look for in a book, it’s probably a good starting point for learning more about what we really know about animal behavior science. Buy Now

  • Veterinary Pharmacy Reference Software, Fast, Friendly and Efficient
    The veterinary industry faces a more informed, more demanding client than ever before. Pet owners are willing to spend more than ever before and expect the same level of service and care that is given by human doctors and pharmacists. Currently drug companies and veterinary practices face countless lawsuits regarding side effects, interactions, and lack of informed consent. Veterinarians have found that the VPR program has dramatically changed the way they are able to do their jobs, saving them and their staff time and money. Client are more informed and excited about the improved service they are receiving. Better communication between veterinarian and client is vital. On the human side, the physician has a pharmacist to help dispense that kind of information. Veterinarians don’t have a pharmacist to help and by the nature of their practice, they are busy, so it’s more difficult to sit and explain every possible side effect to clients. And then, the third party you need is VPR (Veterinary Pharmacy Reference). VPR has been an essential tool for veterinarians for years. Now it is integrated with Impromed Infinity. The drug information is available right from the Infinity Patient Processing module or from a button on the Infinity toolbar. When the medications in VPR directly linked to Infinity product database so that when a drug is added to an invoice, the prescribing information for that Drug, Strength, and Species is already highlighted. Inside The VPR: Interactive Drug Search Client info, sheets with patient specific prescription info Printable Drug Information Anesthesia Consent Forms Interactive Anti-parasitic Charts Dosage calculator Drug interaction matrix with med washout period monitoring weight measurement and temperature conversion charts The current version of VPR is VPR 2.8 build 1. In the newest version of VPR a Dosage & Available Forms section has been added to the Calculator. VPR must be installed on every machine that will be running the program. However the Client/Patient information and history can be shared over a network. VPR will run on most Windows machines currently in use. However, recommended specifications would be at least a 300MHZ processor with 32 mg of memory, and approximately 100mg of free hard drive space. The database updates come every six months to update VPR with the latest drugs and updated dosing information. If you have any problems VPR support is fast, friendly, & efficient. Order Now

  • The Merck Veterinary Manual (Hardcover)
    The ninth edition was increased by 400 pages, and includes additional information on the news and being born diseases of animals, chapters widened on the urgency and critical care, much of chapters additional and revised of other. There is no comparable text which covers the same range, the number of species and the diversity of the topics matter than the Merck veterinary handbook. The hundreds of thousands of veterinary surgeons in the whole world were based on its exactitude and relevance during 50 years. The fiftieth edition of birthday of the resource of confidence in veterinary medicine was intensively revised and updated and includes last the discoveries, made, and practical at the management of the health of the animals. Buy Now…

  • #3: Dog Costume – Hot Diggity Dog Halloween Costume (Hot Dog w/Mustard) – Small
    Dog Costume - Hot Diggity Dog Halloween Costume (Hot Dog w/Mustard) - Small
    Dog Costume – Hot Diggity Dog Halloween Costume (Hot Dog w/Mustard) – Small Casual Canine Average Customer Review: Buy new: .99 .99 9 used & new from .99 (Ranking is updated hourly. Visit the Bestsellers in Pet Supplies > Apparel & Accessories list for authoritative information on this product’s current rank.)

  • Pets Annual Vaccination
    Recently there has been much controversy over annual vaccinations of your pets. Many reports and read dozens of articles on the negative if not deadly effect vaccinations may have on your pet.Many older human and veterinary doctors can recall the devastation of communicable disease, before the advent of vaccinations and antibiotics. The science of veterinary medicine is advancing by leaps and bounds new discoveries and cures are being developed every day. If you have any questions or concerns about vaccinations ask your veterinarian. They, are your companion animals, primary health care professional. Do not rely on second hand information or articles designed to scare and therefore sell more magazines. It has been proven time and again that annual and biannual visits to your veterinarian can extend the life and improve the quality of life of your pet. Take your beloved pet to the veterinarian for a routine health check at least yearly, ask them questions about your animals health and vaccination schedule. If there are any changes or new therapies your veterinarian is your best source of information. source:www.americankennelsupply.com

  • Dog Tips, Unleash Your Dog's Star Potential
    Does your dog have star potential? Does he love to entertain friends and family with his amusing antics – like running in circles to chase his tail, jumping up and down when dinner is served or howling to his favorite song? Many dog owners enjoy capturing these memorable moments on video so they can share them with other dog lovers.

    Unleash Your Dog's Star Potential In some cases, the videos can even make their four-legged friends famous. For example, ALPO brand dog food is searching for the biggest “meat maniac” in America – the lovable, everyday dog who has the most entertaining, humorous and memorable way of showing his excitement when dinner is served. The winning dog will be the new face of ALPO, appearing on millions of cans of dog food and in national print advertising. Dog owners nationwide can visit AlpoRealMeatMoments.com to submit a video of their pooch’s meat maniac moment. Make sure Rover is comfortable on “set.” Before you press the record button, give your furry companion the chance to become familiar with the video equipment, so he doesn’t run away. Let him sniff the camera and reward him with a treat for good behavior. Give Fido creative license. Allow your dog to act natural. Capture his unscripted, real, spontaneous behavior when dinner is being served, rather than a trained trick. Allow him to showcase his transformation from everyday dog to meat maniac in his own unique way. Include audio. Think beyond images. Don’t forget to capture the sounds that will help tell your meat maniac’s story, including any barking, howling, grunting and whining in anticipation of the meaty meal. Turn your spotlight on the star. Lights add depth to any scene. Turn on all of the lights in the room and open the curtains to increase available light, particularly if your dog has a dark coat. Use a hand held technique. Take the camera off of the tripod and move with your dog to best capture his humorous mealtime moves. Look for unusual angles, such as ground-level shots to add interest. source: www.cass-news.com


  • About
    Welcome to The Best Online Veterinary Store. BestVetStore.Com is an online veterinary store that provides all necessary of veterinarian, such as veterinary books, veterinary magazine, veterinary journals, veterinary tools and equipments, medical tools etc. We are one of the leading veterinary store associated with Amazon. Our aims are to become the center of the veterinary stuff and all related products. Soon, the shop becomes the center for veterinarians, veterinary technicians, veterinary assistants and veterinary students and we hope we could fill the needed of veterinary clinic and veterinary hospital on their equipments. Please select the products on the menu category or use the search menu if you can’t find them. Feel free to contact us using the contact form. This site is a part of Vet-indo Network, hosted on DreamHost, Inc. Address: DreamHost, Inc. PMB #257 417 Associated Rd. Brea, CA 92821 USA

  • Slatter's Fundamentals of Veterinary Ophthalmology: With VETERINARY CONSULT Access (Hardcover)
    Slatters Fundamentals of Veterinary Ophthalmology Veterinary Consult Access The Veterinary Consult version of this title provides electronic access to the complete content of this book. Veterinary Consult allows you to electronically search your entire book, make notes, add highlights, and study more efficiently. Purchasing additional Veterinary Consult titles makes your learning experience even more powerful. All of the Veterinary Consult books will work together on your electronic “bookshelf”, so that you can search across your entire library of veterinary books. Veterinary Consult: It’s the best way to learn! Recognize, diagnose, and manage a vast range of common and important ocular conditions with the latest edition of this trusted reference. Extensively revised and updated by a team of internationally respected contributors, this edition provides a comprehensive, yet practically oriented, diagnostic guide to ophthalmic disease, covering structure and function, ocular development, pathology, examination and diagnosis, pharmacology, and emergency management for a wide variety of small and large animal species.



  • Vitamins A and D Injection with Vitamin E for Cattle
    vitamin_a_dVitamins A D Injection with Vitamin E – Antioxidant. A water emulsifiable solution to be used as a supplemental source of Vitamins A and D in cattle sheep and swine. EACH mL CONTAINS: Vitamin A 500 000 I.U. Vitamin D 75 000 I.U. Benzyl Alcohol 2% v/v; Ethyl Alcohol 8% Vitamin E (antioxidant) 5 I.U. B.H.A. 0.75% B.H.T. as preservatives in a base. GET IT NOW Vitamin A is the most important vitamin in cattle nutrition. It is the only one which normally must be added to cattle diets. It is necessary for bone development, sight, and maintenance of healthy epithelial tissues (i.e. lining of digestive and reproductive tracts). A deficiency can cause an increased susceptibility to disease, night blindness and reproductive failure.  Vitamin A needs special attention in beef cattle rations. This vitamin is found only in animals. Plants, however, are the natural source of vitamin A activity for animals. Green and yellow plants contain carotene, a pigment which animals convert to vitamin A. The wall of the small intestine is the principal site for conversion of carotene to vitamin A. Some metabolic functions of vitamin A are not yet known. A chief role is maintenance of epithelial tissue (skin and lining of respiratory, digestive and reproductive tract) in a healthy condition. It also functions in visual purple, a compound in the eye needed for sight when an animal adapts from light to dark. Vitamin A is essential for proper kidney function and normal development of bones, teeth and nerve tissue. One of the first easily detected signs of vitamin A deficiency in cattle is night blindness. An easy way to check for this condition is to place an obstacle in the pathway of cattle and notice if they stumble over it at twilight. Other early signs are loss of appetite, rough hair coat, dull eyes, slowed gains and reduced feed efficiency. Diarrhea and pneumonia may be the first indicators, especially in young animals. Vitamin A injected in the muscle is used more efficiently to increase liver stores than that given in the feed. This method is often used to supply vitamin A to new feeder cattle. The intramuscular injection of 500,000 to 6 million IU of vitamin A in cows two months before calving has been used in numerous experiments with range and farm herds. There has been no benefit in many cases in respect to fertility, calving percentage or weaning weights. Vitamin D is called the sunshine vitamin because ultraviolet light acting on a compound on animal skin changes that compound into vitamin D. Vitamin D is found in sun-cured forages. Animals kept outdoors or fed sun-cured hay do not usually suffer a deficiency, whereas animals kept indoors and fed silage may do so. Animals manufacture their own vitamin D requirements from sunlight and fresh or dry feed. The body also stores sufficient vitamin D to overcome dietary deficiency for several months. Vitamin D is involved in the uptake to Ca and P, so that a vitamin D deficiency resembles a Ca and P deficiency: rickets in the young animals, weak bones in older animals, and a decreased growth rate. Young, growing animals have a greater requirement for vitamin D than mature animals. Under normal conditions, cattle receive adequate vitamin D from exposure to direct sunlight or from consumption of three to four pounds of sun-cured forages daily. Experiments with calves indicate a requirement of approximately 300 IU of vitamin D per 100 pounds of body weight. Vitamin D increases the absorption from the digestive tract and metabolic use of calcium and phosphorus. It helps regulate blood calcium levels and the conversion of inorganic to organic phosphorus. Vitamin D aids in the formation of sound bones and teeth. Its specific role in the prevention of rickets in young animals or osteomalacia in mature animals is associated with its involvement in the metabolism of calcium and phosphorus. Vitamin E and selenium have similar and interrelated functions in the body. Use supplements containing vitamins D and E in addition to vitamin A. They may not always be necessary but cost little to add. Most rations fed to beef cattle in Missouri are adequate in vitamin E. Adding two to five IU of vitamin E per pound to high-grain rations devoid of leafy roughages has increased feedlot cattle performance in a few Corn Belt trials, but not in others. Injecting new feeder cattle with Vitamin E may reduce the incidence and severity of sickness in the starting phase. Vitamin E is contained in green plant material, hay and grain; the concentration in grain decreases during storage. DIRECTIONS: For intramuscular use. May be repeated in two or three months as needed. Calves – ½ to 1 mL Yearlings – 1 to 2 mL Adult Cattle – 2 to 4 mL Lambs – ¼ to ½ mL Growing Lambs – ½ to 1 mL Adult Sheep – 1 to 2 mL Weaning Pigs – ¼ to ½ mL Growing Pigs – ½ to 1 mL Adult Swine – 1 to 2 mL. Store in a dark cool place not above 50°F (10°C). Keep From Freezing. PACKAGED: 100 mL 250 mL and 500 mL vials GET IT NOW or Download the Manufacturer Catalog (Vet Med Direct) article sources: Queensland Gov, Alberta Gov, Missouri Univ.

  • Sterile Surgical Gloves – Latex, Box of 40
    Sterile Surgical latex gloves wrapped individually (set of two). Box of 40 sets. Small = size 6 Medium = size 7-1/2 Large = size 8-1/2. Buy Now

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