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    Dalmatian bladder stones caused by gene that regulates uric acid in humans

    Posted on November 8, 2008, under Misc

    The discovery equips dog breeders with the tools to eliminate that trait from the Dalmatian breed and yields clues to the cause of similar problems in humans. The findings will be published Nov. 7 in the scientific journal Public Library of Science.

    “This defect, which in dogs is peculiar to the entire Dalmatian breed, has been reported for nearly a century and was probably unintentionally introduced as breeders worked to select more distinctive spotting patterns,” said veterinary geneticist Danika Bannasch, lead author on the study.

    “It is now possible that this trait can be removed from the breed by crossing Dalmatians with the normal offspring of the original Dalmatian-pointer breeding that occurred in the early 1970s,” she said.

    By Dec. 1, the Veterinary Genetics Laboratory in UC Davis’ School of Veterinary Medicine will begin offering DNA testing for the mutation in dogs to allow breeders to eliminate the trait. Information on the testing program will be available online at UC Davis Veterinary Genetics Laboratory

    The researchers collected DNA samples as well as urine samples from hundreds of dogs to identify the gene responsible for high levels of uric acid. Genetic analysis of dogs that are a cross between pointers and Dalmatians revealed that gene to be SLC2A9, a gene that recently has been reported to be important in regulating uric acid levels in humans. DNA analysis showed that mutations in the SLC2A9 gene were responsible for the elevated uric acid in the Dalmatians.

    The same mutations also were present in some bulldogs and black Russian terriers, breeds that are not known to be closely related to Dalmatians. This suggests that the gene mutation must be quite old, even predating formation of the Dalmatian breed. Alternatively, the mutation could have been introduced to those breeds by crosses between breeds, the researchers noted.

    Because the gene mutation does not always occur in bulldogs and black Russian terriers, breeders can simply use genetic selection to eliminate the unhealthy trait from those breeds. In Dalmatians, however, the mutation occurs in all dogs, forcing breeders to look outside of the breed to correct the problem. Download the journal in PDF format

    source:www.physorg.com


    Tuttnauer 2340M, Sterilizer/Autoclave for Vet

    Posted on August 13, 2007, under Misc

    Tuttnauer 2340M Autoclave Sterilizer. Used but in excellent condition and it works perfectly. Physically, It has a slight indent in the top left sheet metal (see photos) that could be easily popped out, but it in no way affects the operation of the autoclave. Other than a few light scratches and a few small marks from a Sharpie pen, it is in great condition.

    SPECIFICATIONS:

    Chamber: 9″ x 18″
    Volume: 5gal/19L
    Overall Dimensions: 21.5″ D x 20″ W x 14.4″ H
    Standard Cassettes: 2 full / 2 half
    Tray Dimensions: 6.7″ D x 16.3″ W x .8″ H
    Number of Trays: 3
    Standard Unwrapped Cycle Time: Cold – 30 mins / Hot – 20 mins
    Voltage: 120V
    Frequency: 50/60Hz
    Power: 1400W
    Current: 12A
    Buy Now…


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    Tylan 50 – Tylosin Injectable Antibiotics

    Posted on January 13, 2012, under Veterinary Drug

    TYLAN® 50 Elanco tylosin Injection is a sterile solution of tylosin base in 50% propylene glycol with 4% benzyl alcohol and water for injection. Each mL contains 50 mg of tylosin activity (as tylosin base). For Use in Swine, Beef Cattle and Non-lactating Dairy Cattle Only.

    In beef cattle and non-lactating dairy cattle, Tylan 50 Injection is indicated for use in the treatment of bovine respiratory complex (shipping fever, pneumonia) usually associated with Pasteurella multocida and Actinomyces pyogenes; foot rot (necrotic pododermatitis) and diphtheria caused by Fusobacterium necorphorum and metritis caused by Actinomyces pyogenes.

    Tylan has an antibacterial spectrum that is essentially gram-positive, but it is also active against certain spirochetes, large viruses, and certain gram-negative organisms (not including coliforms). It has also been found to be active against certain Mycoplasma species.

    In swine, Tylan 50 Injection is indicated for use in the treatment of swine arthritis caused by Mycoplasma hyosynoviae; swine pneumonia caused by Pasteurella spp.; swine erysipelas caused by Erysipelothrix rhusiopathiae; acute swine dysentery associated with Treponema hyodysenteriae when followed by appropriate medication in the drinking water and/or feed.

    Side effects consisting of an edema of the rectal mucosa, anal protrusion, diarrhea, erythema, and pruritus have been observed in some hogs following the use of tylosin. Discontinuation of treatment effected an uneventful recovery from the reaction.

    SWINE-Inject intramuscularly 4 mg per pound of body weight (1 mL per 12.5 pounds) twice daily. Treatment should be continued for 24 hours following remission of disease signs, not to exceed 3 days. Do not inject more than 5 mL per site.

    BEEF CATTLE AND NON-LACTATING DAIRY CATTLE – Inject intramuscularly 8 mg per pound of body weight one time daily (1 mL per 6.25 pounds). Treatment should be continued for 24 hours following remission of disease signs, not to exceed 5 days. Do not inject more than 10 mL per site. This formulation is recommended for use in calves weighing less than 200 pounds.

    Discontinue use in cattle 21 days before slaughter. Discontinue use in swine 14 days before slaughter. Do not use in lactating dairy cattle.

    Do not use in calves to be processed for veal.

    Do not administer to horses or other equines. Injection of tylosin in equines has been fatal.

    Do not attempt injection into pigs weighing less than 6.25 pounds (0.5 mL), unless the syringe is capable of accurately delivering 0.1 mL. Adverse reactions, including shock and death may result from overdosage in baby pigs. Do not mix Tylan 50 Injection with other injectable solutions as this may cause a precipitation of the active ingredients. Buy Now


    VetDrug Application for iPhone, iPod, and iPad

    Posted on August 1, 2010, under Veterinary Software

    VetDrug Application for iPhone, iPod, and iPadThe most complete and concise veterinary drug reference. VetDrug is a simple, clean and easy to use veterinary drug reference. It’s loaded with over 100 commonly used veterinary drugs and includes dosing, warnings and potential side effects.

    This comprehensive database contains treatment options for a variety of animals including dogs, cats, and numerous exotic species. The main screen displays two menu available, they are VetDrug and Unit Conversion. The Unit Conversion menu contains Weight and Body surface area, so you can suit your need. For online Veterinary Drug References, you could use Veterinary Formulary by University of Minnesota or Veterinary Product Database by Drugs.com.

    The VetDrug Application gives you the ability to modify drugs that are included with the app as well as add new drugs to personalize VetDrug for your use. You also have the ability to add tablet or bottle pictures. No internet connection required.

    To buy this vet application, simply open your iTunes software, and purchase from iTunes.